Oncology Treatment Options

on

 BRAF Test 

NSAIDs

  • Does not require radiation, chemo or embolism - several ones to choose from depending on how the pup handles it (see NSAIDs section)

Radiation

  • Does not require chemo – radiation has come a long way and is not as hard on people, or our pups, as it used to be… ask for targeted radiation …
  • SRT (stereotactic) usually less sessions (Roscoe had 3) and equally effective as IMRT
  • IMRT (Definitive ) usually 20 sessions over 4 weeks
  • Please also see the "Procedure Radiation Therapy for Rico 626" document posted in the Files section in our FB Group.

Chemotherapy 

  • Does not require radiation
  • Targeted is best to start
  • Check FidoCure – Transforming canine cancer treatment through personalized medicine.
  • Please also see the 3 following documents posted in the Files section in our FB Group
    • Chemotherapy  Introduction for Owners for Rico 625
    • TKI Lapatinib for Rico 623
    • TKI Toceranib (Palladia) for Rico 624 
  • Another targeted chemo that has worked Trametinib
    • “I just wanted to share we tried Trametinib for our guy and I fully credit it to the extra time we got to have with him after the mitoxantrone chemo failed. Seeing the above comment I wanted to note it was a much more affordable option compared to Lapatinib. It is also a targeted chemo but has not yet been through its trails so it’s still considered off label or experimental. (Not sure how many oncologists would even be comfortable prescribing it currently to be honest, but wanted to throw it out there). I’m also not trying to push one way or the other- just want to say in the end I’m happy we tried it.”
  • From Dr Looper Roscoe’s Oncologist at LSU
    • Many of the prostate cancer patients have cancer originating from the urothelial cells (the cells that line the urethra and bladder). These tumors are typically locally aggressive, but do not have a high risk of spreading. Because of this, local treatments work better than systemic treatments that hit the whole body and are not as targeted.
    • Our local treatment options are surgery and radiation. Chemo, as a systemic treatment, is not very effective at slowing down the tumor in that location.
    • Since surgery is difficult, fraught with complications, and unlikely to be curative, that is why we usually recommend radiation.
    • It is a non-invasive, targeted way to "zap" the tumor without incisions or systemic side effects.
    • It is also not likely curative but much better than chemotherapy at shrinking the tumor and providing some relief, often for a year or more when stereotactic (SRT) protocols are used.

Embolization 

  • May require chemo (link from UC Davis says “minimally invasive”)
  • So far seems to provide the same results as SRT radiation or targeted chemo
EGFR (Yale) Vaccine
Penn State Clinical Trial

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